A Changing Gut Microbiome May Predict How Well You Age

Of these, about 900 were seniors who underwent regular checkups at medical clinics to assess their health. Dr. Gibbons and his colleagues found that in midlife starting at age 40, people began to show different changes in their microbiomes. A decline in the most dominant strains in their guts was observed, while other, less common strains became more prevalent, causing divergence of their microbiomes and appearing more and more different from others in the population.

“We found that in different decades of life, individuals become different – their microbiomes become more and more unique from one another,” Dr. Gibbons said.

Those who made the most changes in their microbial compositions went on to have better health and longer life spans. They have high vitamin D levels and low levels of LDL cholesterol and triglycerides, a type of fat in the blood. He required fewer medications, and had better physical health with faster walking speed and greater mobility.

Researchers found that the blood of these “unique” individuals contained high levels of many metabolites, which are produced by the germs of the gut, including the intestines, which have been shown to reduce inflammation and maintain the integrity of the inhibitor lines. Protect and protect the intestine. In some studies, Scientists have found that giving indole to mice and other animals helps them stay young, making them more physically active, mobile and resistant to disease, injuries and other stresses in old age. One of the metabolites identified in the new study was phenylacetylglutamine. It is not clear what this compound does. But some experts believe that it promotes longevity as research has shown Centenary in Northern Italy Its level is very high.

Dr. Wilmansky found that people whose gut did not undergo much change in the microbiome were in poor health as they grew older. They had higher cholesterol and lower levels of triglycerides and vitamin D. They were less active and could not walk faster. He used more drugs, and was almost twice as likely to die during the study period.

Researchers speculate that some intestinal worms that may be innocuous or perhaps even beneficial in early adulthood may be harmful in old age. For example, the study found that among healthy people who saw the most dramatic changes in their microbiome compositions, there was a steep decline in the prevalence of bacteria called bacteroids, which are more common in developed countries where people eat a lot of processed foods with fat. , Sugar and salt, and is less prevalent in developing countries where people eat a high fiber diet. When fiber is not available, Drs. Bacteroids “chew on mucus”, Gibbons said, such as the protective mucus layer that covers the intestine.

“Maybe it is good when you are 20 or 30 years old and are producing a lot of mucus in your bowels,” he said. “But as we grow older, our mucus layers increase, and perhaps we may need to suppress these insects.”

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