Have You Had Covid-19? Study Says You May Need Only One Vaccine Dose

Shannon Romano, a molecular biologist, came with Kovid in late March, about a week after he and his colleagues closed their laboratory at Mount Sinai Hospital. A debilitating headache came first, followed by a fever that was steadily increasing, and then a body ache. “I couldn’t sleep. I couldn’t walk, “she said. “Only one of my joints hurt.”

This was not an experience she wanted to repeat – ever. So when she became eligible for the Kovid-19 vaccine earlier this month, she was shot.

Two days after her injection, she developed symptoms that felt very familiar. “The way my head hurt and the way my body ached was the same headache and body ache I had when I had Kovid,” she said. She recovered quickly, but her body’s rapid reaction to the jaw surprised her.

A new study may explain why Drs. Romano and many others, who have reported to Kovid, have unexpectedly intense reactions to the first shot of the vaccine. in Study posted Online on Monday, researchers found that people who had previously been infected with the virus reported fatigue, headaches, chills, fever, and muscle and joint pain after the first shot, which had never been infected. Kovid survivors also had higher antibody levels after both the first and second doses of the vaccine.

Based on these results, researchers say, people who have Kovid-19 may only need one shot.

“I think a vaccination should be enough,” said Florian Kramer, a virologist and an author on the study at the Icahn School of Medicine in Mount Sinai. “It will also separate individuals from unnecessary pain upon receiving a second dose and it will release the additional vaccine dose.”

one moment Study released on Monday Enhances the idea. The research involved 59 health care workers, of whom 42 were previously Kovid (with or without symptoms). Researchers did not assess the side effects, but they found that people who had been previously infected responded to the first jab by generating higher antibody levels, a quantity seen after the second dose in people who had never been infected. Was equal to And in laboratory experiments, those antibodies associated with the virus prevented cells from entering. To stretch the vaccine supply, the authors conclude that those who have previously had Kovid should be taken down the priority list and receive only one dose of the vaccine, while supplies are limited.

While some scientists agree with this argument, others are more cautious. Changing the number of doses can “make a really hard precedent”, e. Said John Wherry, director of the University of Pennsylvania Institute of Immunology. “We don’t take FDA approval for, say, a chemotherapy drug and then just throw out the dosing schedule,” he said.

Dr. Wheeree also reported that people who had mild cases of Kovid have lower antibody levels, and may not have protection from more infectious variants of the virus. It can also be difficult to identify which people have been infected before. “The document that actually becomes a potentially messed up public health issue,” he said.

Side effects after vaccination are completely expected. They show that the immune system is increasing a response and will be better prepared to fight an infection if the body comes into contact with the virus. Pfizer and Modern vaccines are particularly good at giving a strong response. Most participants in the companies’ tests reported pain at the injection site, and more than half reported fatigue and headaches.

Clinical trials of authorized vaccines from Pfizer and Moderna, each involving more than 30,000 participants, suggest that most people experience the worst side effects after the second jab. And in modern studies, people who were previously infected actually had fewer side effects than those who were not.

But spontaneously, researcher Drs. Hearing from a growing number of people like Romano who were feeling ill after a shot. “They strictly describe these symptoms,” Dr. Wheary said.

It matches that Drs. What Kramer and his colleagues found in their new study, which has not yet been published in a scientific journal. Researchers assessed symptoms after vaccination in 231 people, 83 of whom were previously infected, and 148 were not. Both groups experienced widespread pain at the injection site after the first dose. But people who became infected more often before fatigue were reported to have headaches and chills.

The team also looked at how the immune system responded to the vaccine in 109 people – 68 of whom had not been previously infected and 41 who had – and found a more robust antibody response in the latter group. However, the number is small, and therefore the study’s conclusion will need to be examined with more research, experts said.

It is not necessarily surprising that previously infected individuals may experience more intense reactions. Both shots contain fragments of genetic material that induce the body to produce spike proteins, the nubri protrusions on the surface of the coronovirus. Those who have already been infected with the virus contain immune cells that are primed to recognize these proteins. So when proteins appear after vaccination, some of those immune cells go on the attack, making people feel sick.

Dr. ophthalmologist in Michigan. Susan Malinowski, who had a Kovid-19 in March, certainly felt her body was attacked after a modern vaccine was introduced. She got her first shot at lunch on New Year’s Eve. By dinner she started feeling ill. He spent the next two days in bed.

“I had a fever. I had a cold. I had night sweats. There was pain everywhere in my body, ”he said. “I was actually more ill after the vaccine with Kovid.”

Questions about more severe vaccine reactions among those who have already been Kovid came at an expert committee meeting on 27 January, which advises the Centers for Disease Control and Prevention.

A committee member of the research institute of Nationwide Children’s Hospital in Columbus, Ohio, Drs. Pablo J. Sanchez said he had heard from people who had a reaction to the vaccine that was worse than his previous experience with the Kovid-19. He suggested that a question about pre-infection be added to the information that the CDC requests vaccine recipients. “It has not been asked,” Dr. Sanchez said. “I don’t think it’s really important.”

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Answers to your vaccine questions

Currently more than 150 million people – about half the population – are eligible for vaccination. but Each state makes the final decision about who goes first. The country’s 21 million health care workers and three million residents of long-term care facilities were previously eligible. In mid-January, federal officials urged all states To open eligibility All adults 65 and older with medical conditions at high risk of becoming seriously ill or dying of Kovid-19. Adults in the general population are behind the line. If federal and state health officials can overcome bottlenecks in vaccine delivery, all 16 and older will become eligible by this spring or early summer. The vaccine has not been approved in children, although studies are ongoing. It may be months before the vaccine becomes available to anyone under 16 months of age. Go to your state health website For up-to-date information about vaccination policies in your area

You should not give anything out of pocket to get vaccinated, Although you will be asked for insurance information. Even if you do not have insurance, you should be given the vaccine at no charge. Congress passed legislation this spring to prohibit insurers from sharing any costs, such as co-pays or deductibles. It provides additional protection from billing patients to pharmacies, doctors and hospitals, including those. Still, health experts worry that patients may be weak Leave the bills surprising them. This can happen to people who are charged with a doctor visit with a vaccine, or Americans who have certain types of health coverage that are not covered under the new regulations. If you receive your vaccine from a doctor’s office or urgent care clinic, talk to them about a possible hidden fee. To ensure that you do not get a surprise bill, the best bet is to get your vaccine delivered to the health department’s vaccination site or local pharmacy after shots become more widely available.

It is to be determined. It is possible that the Kovid-19 vaccination will become an annual phenomenon like the flu pill. Or it may be that the benefits of the vaccine stay for more than a year. We will have to wait to see how durable the protection from vaccines is. To determine this, researchers are going to monitor vaccinated people to look for “cases of success” – people who get sick from Kovid-19 despite being vaccinated. This is a sign of weakening safety and will give researchers clues about how long the vaccine lasts. They will monitor the levels of antibodies and T cells in the blood of vaccinated people to determine if and when a booster shot may be required. It is predictable that people may need boosters every few months, once a year or only a few years. It is just a matter of waiting for the data.

CDC’s Dr. Tom Shimbukuro, who presented security data to the committee, said the agency was investigating the issue. “There is limited data on that right now, but we are looking at ways through which we can get better information,” he said.

Akiko Iwasaki, an immunologist at the Yale School of Medicine, said people approaching Kovid felt “reacting to the first dose, as if it were the second dose.” So one dose is probably “more than enough,” he said.

a Study It was published earlier this month that being re-infected during five months provided 83 percent protection from surviving natural infections. He said “giving two doses over it may cause overkill.”

Shane Kratty, an immunologist at the La Jolla Institute for Immunology, pointed out that generally more intensive vaccine response is better protection. If one had a large reaction to the first dose, “I hope it would be wise to skip that second dose and also that the second dose is probably unnecessary,” he said.

But other immunologists suggest that everyone take two doses. “I’m a big proponent of the right dosage and the right program, because that’s how the study was done,” said Maria Elena Botazzi, an immunologist at the Boiler College of Medicine in Houston.

And getting two shots is not a threat to those who have Kovid.

Nevertheless, ophthalmologist Dr. Malinowski wished that the questions were shorter and the answers more. If the side effects of the vaccine are actually more acute in people who have already been infected, health officials can give people a head, she said.

“It would be nice to know that, hey, you can’t get out of bed for two days,” Malinowski said. He has decided not to return for a second dose.

Dr. of Mount Sinai Hospital Romano is due for his second shot in February, and is not sure what he will do. “My friends who are immunologists, we are all discussing it among ourselves,” she said. “Chances are I’ll probably get it.” But I want to think a little more about it before doing so. “

Dennis Grady and Apoorva Mandavili contributed reporting.

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