Many ‘Long Covid’ Patients Had No Symptoms From Their Initial Infection

Many people who experience long-term symptoms from coronovirus when they were not initially infected, according to them, were not ill at all. New study Which adds compelling information to the increasingly important issue of the lasting health effects of Kovid-19.

The study, previously focused specifically on those who never needed hospitalization when they were infected, analyzed the electronic medical records of 1,407 people in California who tested positive for coronavirus Used to do More than 60 days after their infection, 27 percent, or 382 people, were struggling with post-Kovid symptoms such as shortness of breath, chest pain, cough, or abdominal pain.

Researchers found that approximately one-third of patients with such long-term problems during 10 days had no symptoms of their initial coronavirus infection.

Understanding long term Kovid symptoms is one Fast pressing priority As doctors and researchers report more and more people have debilitating or painful aftereffects that hinder their ability to work or the way they act before. Last month, the director of the National Institutes of Health, Drs. Francis S. Collins announced Big initiative “To identify the causes and means of prevention and treatment for those who have been terminally ill with Kovid-19, but do not fully recover in a few weeks.”

David Putrino, director of rehabilitation innovation at Mount Sinai Health System in New York City, who was not involved in the new research, said he and his colleagues are seeing a similar pattern at Mount Sinai’s center for the care of Kovid.

“Many people who had asymptomatic Kovid may also develop post-acute Kovid syndrome,” Dr. Putrino, who co-authored a short Study on the subject published last year. “This does not always coincide with the severity of acute symptoms, so you may not have any symptoms but still have a very aggressive immune response.”

The new study is published on the preprint site MedRxiv and is not undergoing peer review. Its strengths include that it is larger than many studies on long-term symptoms published so far and researchers used electronic records from the University of California, which allowed them to obtain patients’ health and demographic information from across the state. Researchers have also excluded study symptoms that patients reported in the year prior to their infection, a move aimed at focusing on post-covariate symptoms.

Among his findings: Long-term problems affect every age group, including children. “Of the 34 children in the study, 11 were tall-skinned,” said one of the authors, Melissa Pinto, an associate professor of nursing at the University of Irvine, California.

The study found more than 30 symptoms, including anxiety, low back pain, fatigue, insomnia, gastrointestinal problems, and a rapid heart rate. Researchers identified five groups of symptoms that were most likely to occur simultaneously, such as chest pain and cough or abdominal pain and headaches.

Most previous studies of long-term symptoms have included people who were ill enough from their initial infection to be hospitalized. One of the largest found that more than three-quarters About 1,700 hospitalized patients in Wuhan, China, Had at least one symptom six months later.

But increasingly, those who were never hospitalized are seeking care in post-Kovid clinics, and scientists are recognizing the need to understand their circumstances.

In the last month, researchers University of Washington reported on a survey of 177 people Who tested positive for coronavirus. Most of them were not hospitalized. Researchers found that one-third of both people were hospitalized and those who had only mild initial illnesses reported having at least one permanent symptom six months later.

Unlike some recent surveys, such as one by one A patient-led research teamThe new study did not capture one of the most commonly reported “long covid” issues: cognitive problems such as brain fog, Memory problems and difficult focusing. One of the co-authors, Natalie Lambert, Associate Research Professor at Indiana University School of Medicine, said that at that time, doctors may have to include diagnostic codes for such cognitive issues in Kovid patients’ medical records Can not be known for . He said the team is seeking funding for a larger and more comprehensive study, which adds information to medical records, doctors ‘notes and patients’ reports.

In the new study, about 59 percent of patients with long-term symptoms were female, and about half of the patients were Hispanic and 31 percent were white. The authors and Drs. Putrino cautioned that any reliable demographic conclusion would require large studies that are within the national scope.

Dr. Lambert said that it was likely that the medical records used in the study were only visible to a few percent of people who had asymptomatic Kovid infections and had post-Kovid experiences. “For some people, if they’re asymptomatic and they don’t know they’re sick, they’re not going to do the test,” she said.

“Another important component is that we know that some long-lasting symptoms appear much later than two months,” Dr. Lambert said. “So there is a potential for a wide range of long-lasting symptoms that they are not going to associate with Kovid.”

Dr. Pinto said it would be important to study the situation over time rather than static snapshots. “The long run is a very dynamic process and the symptoms can change from day to day,” she said. “One day they may have chest pain and headache, and the next day, they get chest pain and headache and they have backache and muscle aches. We need to capture the change of trajectory and symptoms over time, and we need this in a larger sample that represents America. “

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