New Findings on 2 Ways Children Become Seriously Ill From the Coronavirus

a Large nationwide study Significant differences have been found in the two major ways in which children became seriously ill with coronovirus, findings that help doctors and parents better identify the conditions and understand more about the children at risk for each can do.

The study, published Wednesday in the journal JAMA, analyzed 1,116 cases of youth being treated in 66 hospitals in 31 states. More than half of the patients had acute Kovid-19, a predominantly lung-related disease that afflicted most of the adults who were ill with the virus, compared with 539 patients. Inflammatory syndrome The disease usually occurs in some children a few weeks after a mild initial infection.

Researchers found some similarities, but also found significant differences in the symptoms and characteristics of patients, ranging from infants to 20-year-olds and were hospitalized between March 15 and October 31 last year.

Youth with the syndrome called Multisystem inflammatory syndrome in children or MIS-C, Were more likely to be between 6 and 12 years of age, while more than 80 percent of patients with acute Kovid-19 were under 6 or over 12.

More than two-thirds of patients had either the condition Black or Hispanic, which experts say most likely reflects socioeconomic and other factors that have exposed some communities to the virus.

“It is still shocking that the overwhelming majority of patients are nonvegetated and this is true for MIS-C and for acute covariates,” Dr. Gene A. Ballweg, Children’s Hospital and Medical Director for Pediatric Heart Transplant and Advanced Heart Failure for Dr. Center in Omaha, which was not included in the study. “There is clearly racial inequality there.”

For reasons that remain unclear, while Hispanic youth were equally likely to be at risk for both conditions, black children appeared to be at greater risk for developing inflammatory syndrome than acute illness, Dr. Adrienne Randolph, senior The author said. Studies at Boston Children’s Hospital and a pediatric critical care specialist.

A possible clue mentioned by the authors is that with Kawasaki disease, there is a rare childhood inflammatory syndrome There are similarities with some aspects of MIS-C, Black children show a greater frequency of cardiac abnormalities and are less sensitive to one of the standard treatments: intravenous immunoglobulin.

Researchers found that young people with inflammatory syndrome were significantly more likely not to have an underlying medical condition than acute covariates. Nevertheless, more than one-third of patients with acute covariates had no medical condition before. “It’s not like already healthy kids are completely free from here,” Dr. Randolph said.

The study evaluated obesity separately from other underlying health conditions and only in patients who were 2 or older, finding that there was obesity among young people with somewhat acute covariates.

University of British Columbia pediatrician Drs. Srinivas Murthy, who was not involved in the study, said he was not convinced that the findings showed that healthy children were at higher risk for MIS-C. He said, “It could be a numbers game with the proportion of mostly infected children and healthy children getting out of there, instead of saying that healthy children have some immunity that puts them at very high risk ,” They said.

Overall, he said, the study documentation of the difference between the two conditions was useful, especially because it reflected “a representative representative of hospitals across America”.

Young people with inflammatory syndrome require treatment in intensive care units. His symptoms were more likely to include gastrointestinal problems, inflammation, and skin and mucous membranes. The study stated that they were more likely to have heart-related problems, although many severe Kovid patients did not receive detailed cardiac assessments.

Roughly the same large proportion of patients with each condition – more than half are needed, respiratory support, slightly less than one-third of the need for mechanical ventilation. Roughly the same number of patients died in each group: 10 with MIS-C and eight with acute Kovid-19.

Data does not reflect Recent increase in cases of inflammatory syndrome Kovid-19 infections increased across the country during the winter holiday season. Some hospitals have reported that the current wave has a higher number of seriously ill MIS-C patients compared to previous waves.

Dr. Ballweg said, “I’m going to be fascinated with this group going forward on November 1 because I think we all feel that children with MIS-C have become even more ill recently.”

An optimistic indication from the study was that most of the severe heart problems in young people with inflammatory syndrome improved to normalcy within 30 days. Nevertheless, Drs. Randolph said that any residual effects were still unknown, which is why his co-author, Drs. Jane Neuberger is a pioneer in the Cardiology Department of Boston Children’s Hospital as Associate Chief of Academic Affairs, Nationwide study Adherence to children with inflammatory syndrome for up to five years.

Dr. “We can’t say 100 percent to make sure everything can be normal long term,” Randolph said.

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